Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning..Among the FGF proteins, the least characterized superfamily is the group of fibroblast growth factor homologous factors （FHFs）. The fibroblast growth factor （FGF） family includes 22 genes found in humans that share sequence and structural similarity. FGFs fall into three major groups: canonical FGFs （comprising subfamilies 1, 4, 7, 8 and 9）, endocrine FGFs, referred to as the FGF19 subfamily, and fibroblast growth factor homologous factors （FHFs）, until recently considered intracellular FGFs, termed the FGF11 subfamily.